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Moderate violations of liver and kidney function, with arrhythmias or predisposition to arrhythmias and prolongation of the QT interval, with the combined administration of terfenadine, warfarin, digoxin.
Use during pregnancy and lactation
During pregnancy, the drug is prescribed only when the expected benefit to the mother exceeds the potential risk to the fetus.
If it is necessary to use the drug during lactation, the issue of stopping breastfeeding for the duration of the drug should be resolved.
Methode of administration and dosage
Inside, 1 time a day, at least 1 hour or 2 hours after meals. Adults (including the elderly) and children over 12 years of age with a body weight of over 45 kg.
For infections of the upper and lower respiratory tract, ENT organs, skin and soft tissues – 0.5 g / day for 1 reception for 3 days (course dose – 1.5 g).
With migrating erythema (Lyme disease) for the treatment of stage I – 1 time a day for 5 days: day 1 – 1.0 g, then from day 2 to day 5 – 0.5 g daily (course dose – 3 g).
Acne vulgaris – 6 g course dose, 0.5 g / day for 1 reception for 3 days, then 0.5 g / day once a week for 9 weeks. The first weekly tablet should be taken 7 days after taking the first daily tablet (8 days from the start of treatment), the next 8 weekly tablets – at intervals of 7 days.
For infections of the genitourinary tract caused by Chlamidia trachomatis (uncomplicated urethritis or cervicitis) – once 1 g.
Administration to patients with impaired renal function: for patients with moderate renal impairment (creatinine clearance > 40 ml / min), dose adjustment is not necessary.
Zithromax. Side effects
From the circulatory and lymphatic systems: thrombocytopenia, neutropenia.
From the central nervous system:dizziness/vertigo, headache, convulsions, drowsiness, paresthesia, asthenia, insomnia, hyperactivity, aggressiveness, anxiety, nervousness.
From the sensory organs: tinnitus, reversible hearing impairment up to deafness (when taking high doses for a long time), impaired perception of taste and smell.
From the side of the cardiovascular system from the side of the cardiovascular system:palpitations, arrhythmia, ventricular tachycardia, increased QT interval, bidirectional ventricular tachycardia.
From the gastrointestinal tract:nausea, vomiting, diarrhea, abdominal pain / cramps, flatulence, digestive disorder, anorexia, constipation, discoloration of the tongue, pseudomembranous colitis, cholestatic jaundice, hepatitis, changes in laboratory parameters of liver function, liver failure, liver necrosis (possibly fatal).
Allergic reactions: itching, skin rashes, angioedema, urticaria, photosensitization, anaphylactic reaction, including edema (in rare cases fatal), erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis. From the musculoskeletal system: arthralgia.
From the genitourinary system: nephritis, acute renal failure.
Other: vaginitis, candidiasis.
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