Description
Looking for a pharmacy where you can order Zofran online cheep? You can click on the button and go to the drugstore with the best prices. Anonymous delivery, quality drugs, complete confidentiality. Go to an online shop and choose the appropriate Zofran dosage, and then the required amount of pills. The purchase process will be as secure and safe as possible. You can also buy Zofran with fast delivery at the drugstore, the medicine will be delivered tomorrow. The purchase is made without a prescription because we trust you and understand that you already know which medicine you need.
Special instructions
In some cases, individuals with a history of hypersensitivity to other serotonin 5HT3 receptor antagonists have allergic reactions to ondansetron. Since it is known that ondansetron increases the passage time of the contents through the colon, in the case of the drug in patients with symptoms of subacute intestinal obstruction, regular monitoring is necessary. Use in pediatrics Currently, there are limited data on the use of ondansetron in children under the age of 1 month. Influence on the ability to drive vehicles and mechanisms Zofran® it does not have a sedative effect and does not affect the ability of patients to drive vehicles or engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Overdose
Currently, there is little data on overdose of ondansetron. Symptoms: in most of the observed cases, the symptoms of overdose coincided with adverse reactions that occur when taking Zofran® in the recommended doses. Treatment: there is no specific antidote for Zofran, therefore, if an overdose is suspected, symptomatic and supportive therapy is recommended. Drug interaction There is no evidence that ondansetron induces or inhibits the metabolism of other drugs often prescribed in combination with it. According to special studies, it was found that ondansetron does not interact with ethanol, temazepam, furosemide, tramadol and propofol. Ondansetron is metabolized by several isoenzymes of the cytochrome P450 system (CYP3A4, CYP2D6 and CYP1A2). Due to the variety of isoenzymes capable of metabolizing ondansetron, inhibition of isoenzymes or a decrease in the activity of one of the isoenzymes (for example, with a genetic deficiency of CYP2D6) is usually compensated by other isoenzymes, as a result of which changes in the total clearance of ondansetron are either absent or insignificant and practically do not require dose adjustment. Data on deep arterial hypotension and loss of consciousness during the use of ondansetron with apomorphine hydrochloride were obtained, given this, this combination is contraindicated. In patients receiving powerful inducers of CYP3A4 (phenytoin, carbamazepine and rifampicin), the concentration of ondansentron in the blood was reduced. There is evidence from small studies indicating that ondansetron may reduce the analgesic effect of tramadol.
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